![]() Wetting and dispersion times decreased from 46 to 38 s by increasing the SSG concentration from 3.33 to 6.66% w/w in tablets prepared by superdisintegration method. Tablet hardness and friability indicated good mechanical strength. The results of micromeritics studies revealed that all formulations were of acceptable to good flowability. IR studies indicated that there was no interaction between the drug and the excipients used except Ludipress. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including IR spectroscopy, micromeritics properties, tablet hardness, friability, wetting time, disintegration time and in-vitro drug release. Sodium starch glycolate (SSG) was used as the superdisintegrant. ![]() Different combined approaches were proposed and evaluated to optimize tablet characteristics. Orodispersible tablets were prepared by direct compression technique using three different approaches namely super-disintegration, effervescence and sublimation. ![]() The present study aimed to formulate orodispersible tablets of flutamide (FTM) to increase its bioavailability.
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